Twenty One Hotel

Top rated by guests
Exterior view
Twenty One Hotel Hotel in Rome
Lobby
Twenty One Hotel Hotel in Rome
Bathroom
Don't miss out! Price and availability may change
8.2 / 10
Excellent(295 Ratings)

Hotel in Rome

4-Star Hotel

Reasons to book

Guests love it hereGuests give this property a top rating
High-end valueWell priced for this area
Book with confidenceWe partner with the top travel sites so you know you're getting a great deal on the perfect rental

About this hotel

Twenty One Hotel provides flawless service and all the necessary facilities for visitors.

Stay connected with your associates, as complimentary Wi-Fi is available during your entire visit. To facilitate your arrival and departure, you can pre-book airport transfer services prior to checking in. The hotel offers car hire and shuttle amenities for your ease in navigating around Rome.

When arriving by car, take advantage of the hotel's convenient on-site parking facilities.

The hotel offers reception amenities including concierge service, express check-in or check-out, luggage storage and safety deposit boxes to ensure a comfortable stay for guests. Should you require assistance, the ticket service and tours can also aid in booking tickets and securing reservations at the finest shows and events in the vicinity. Whether it's an extended stay or simply needing fresh attire, dry cleaning service and laundry service provided by hotel ensures your cherished travel garments stay spotless and accessible. Your stay will be comfortable with the presence of 24-hour room service, room service and daily housekeeping as an in-room amenity for your relaxation and enjoyment. To ensure the well-being and convenience of all visitors, smoking is strictly prohibited throughout the entire hotel.

Smoking is permitted solely in the specified smoking zones allocated by hotel. In order to ensure the utmost level of relaxation, the guestrooms feature an inviting design and are equipped with all basic necessities, creating a delightful stay experience.

To ensure a pleasant stay, a selection of rooms at hotel come furnished with linen service and air conditioning, all designed with your ease in mind. Several chosen accommodations at Twenty One Hotel have a balcony or terrace incorporated into the room design.

In select rooms, visitors can enjoy a touch of amusement with the availability of television and cable TV for their entertainment needs. Within specific rooms, a refrigerator, a coffee or tea maker and mini bar is conveniently available for your use.

Understanding the significance of bathroom facilities in enhancing visitor contentment, hotel offers a hair dryer and toiletries within a few chosen chambers. Start your day stress-free at Twenty One Hotel as breakfast is made available for you on the premises. How about kicking off each day of your getaway with a delicious cup of coffee? At the hotel, relish in the invigorating taste of a freshly brewed, excellent coffee.

Various excellent meal offerings at hotel ensure that enticing and easily accessible options are constantly available. Upon your arrival, don't miss experiencing bar for enjoyable in-house evening entertainment. Twenty One Hotel provides a superb assortment of leisure amenities for guests to enjoy. Unwind effortlessly each day by exploring the salon, conveniently situated within the hotel.


Amenities at Twenty One Hotel

Free WiFi/internet
Free breakfast
Free Parking
Air conditioning
Non-smoking
Gym
Wheelchair accessible
Kitchen
WiFi/Internet
Parking Available
Garden
Laundry services
Family friendly
Smoking allowed
Contactless check-in/out
Cleaning products

Map of Rome


Available Rooms

Things to know

Check-in: 3:00 PM
Check-out: 11:00 AM
Early check-ins and late check-out requests will be accommodated upon request and based upon availability. Unauthorized early check-ins and late checkouts will incur a penalty fee.
House rules
  • Kids allowed, fees apply
  • No smoking allowed inside or outside, fines apply
  • No parties or events allowed without prior approval, fees apply
  • Must be 25 or older to rent

Additional fees to expect

Cleaning & other feesWe include all stay related fees in the Cleaning Fee line, which may include cleaning, property manager, resort, tourism and other stay related fees. All Vogo properties are professionally cleaned after each stay.
Booking feeNo booking fees, easy credit card payments.
Service feeThis helps Vogo provide a safer and more secure booking experience.
TaxesTaxes on accommodation such as Occupancy Tax, VAT, or GST. May also include tourism fees.

Customer support

Customer support is handled by our partner Vogo

    Ratings and reviews

    8.2 / 10
    Excellent(295 Ratings)
    8.0 / 10Excellent·Dec 2025
    1. Location is superb, within walking distance to St. Peter basilica, resto, supermarket etc. the area is safe. 2. Hotel is clean even though is a bit small considering 4* hotel. 3. Price wise quite reasonable as it’s include good breakfast. 4. The only problem is the housekeeping not careful enough taking my bath towel as it’s similar with the hotel’s towel. (White colour but smaller size) 5. The hotel shuttle to FCO is more expensive than taking Uber Black which is only euro 58 during wee hour. If it’s normal hour could be cheaper. So, take Uber black is well recommended.
    7.2 / 10Good·Nov 2025
    Very out of the way and not that close to the Vatican or the nearby metro station. Situated in a quiet neighborhood and the room was okay, but the bed was the smallest we've had in Italy and not that comfortable. Bathroom not the cleanest but if you don't mind the location it's okay.
    9.6 / 10Outstanding·Jul 2025
    We – two adults and an 11-year old – booked this hotel blind, knowing nothing about it. What a surprise. The place was well-run, clean, and front desk incredibly helpful – Emmanuel coordinated retrieving my cellphone that I’d accidentally left in a taxi – and generous with their assistance and knowledge. After booking 2 nights before a longer trip out of Rome, we booked another 3 nights on the return because we liked our previous stay so much. The hotel is well-located in a quiet neighborhood away from the tourist traffic, but also no more than a 30-minute walk from the Vatican and the Piazza del Popolo. Lots of non-tourist trap restaurants and bakeries nearby, some of them quite amazing. All in all, we would book here again in a heartbeat and look forward to doing so. Mille Grazie, Twenty One!
    6.8 / 10Average·Sep 2024
    The hotel is great and in a great location. The room was smelling weird and the bathroom smelled too. Beds are somewhat comfortable, not so much but the breakfast was amazing with a great view.

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    FAQs

    Is parking included with this hotel?

    Yes, parking is listed as an amenity at Twenty One Hotel. For more information, we encourage you to contact the property about where to park.

    Is there a pool at this hotel?

    We didn’t find pool listed as an amenity for this hotel. It may be worth double checking if a pool is important for your stay.

    Is Twenty One Hotel pet friendly?

    Unfortunately, this hotel is not pet-friendly. Try searching again and filter for "Pets Allowed"

    What amenities are available at Twenty One Hotel?

    We found 16 amenities for this rental. This includes free wifi/internet, free breakfast, free parking, air conditioning, and non-smoking.

    What payment types are supported?

    This property accepts Visa, Mastercard, American Express, Discover, and Diners Club. Some card brands may not be accepted if you are located in a country or using a currency they don't support.


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